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Clinical studies indicate that stopping GLP-1 therapy abruptly can lead to weight regain due to hormonal and metabolic adaptations

A: GLP-1 receptor agonist medications have undergone extensive clinical testing and are FDA-approved for use in adults with obesity

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Emerging evidence has suggested that obesogenic diets, including high-fat components, could alter GLP-1 production by affecting the gut microbiota [25,26,27,28,29]

Numerous practice guidelines recommend multicomponent, evidence-based nutritional and behavioral therapy for adults with obesity, but use of such treatments with GLP-1s is not widespread [73]
