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2025, [7] J

This is a composite, and individual results vary widely but it captures a pattern I now see often enough that I ask about metabolic inflammation at nearly every RA visit

For example, many L-cells in the distal jejunum and ileum coexpress GLP-1 and PYY (14), whereas proximal L-cells can also produce GLP-1 (15), in addition to secreting CCK, GIP, neurotensin, or secretin (16)

Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference for Patients With Obesity or Overweight: A Systematic Review, Meta-analysis, and Meta-regression of 47 Randomized Controlled Trials

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The paper also found that former users of a wider list of weight-loss drugs regain weight four times more quickly than those who had used behavioral techniques like dieting or exercise