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Pancreatic -Cell Protection and Function In pancreatic -cells, GLP-1 receptor activation enhances glucose-stimulated insulin secretion by increasing intracellular cAMP production, which leads to protein kinase A phosphorylation and activation of exchange protein directly activated by cAMP (Epac)

Anna Nat Acad Med Sci

Our findings revealed EC 50 values of 3.97 nM and 2.43 nM for GLP-1R internalization mediated by GEP44 and Ex-4, respectively, and EC 50 s of 1.59 nM and 7.13 nM for GEP44 and Ex-4, respectively, for -arrestin-2 recruitment

The wall of the colon contains two groups of muscles, a circular muscle that rings the colon and three long muscles that run the entire length of the tube

LYZ and SZ revised the work critically for important intellectual content

GLP-1 and weight loss: unraveling the diverse neural circuitry