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although several studies found improvements in steatosis and inflammation, they did not show significant changes in fibrosis 35

23-25 Despite those studies showing an overall long-term benefit of tight sugar control in preventing worse retinopathy, a small percentage of subjects had a paradoxical early worsening seen in the first year

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A complex puzzle Gloyns team first observed GLP-1 resistance nearly 10 years ago, before the explosion of interest in GLP-1 receptor agonists as weight-loss drugs

[DOI] [PubMed] [Google Scholar] 58.Dhanapalaratnam R, Issar T, Lee ATK, Poynten AM, Milner K-L, Kwai NCG, Krishnan AV

We used the AalenJohansen estimator to estimate cumulative incidences of discontinuation and reinitiation, and FineGray sub-distribution hazard models to assess the association of clinical variables with the risk of discontinuation