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He L, Wang J, Ping F, Yang N, Huang J, Li Y, et al

If you notice a rash that spreads, significant pain, or warmth that seems unusual, it is important to reach out promptly so your healthcare provider can rule out infection or an allergic response

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Some clinicians advocate extending the time at lower doses if symptoms are troublesome

For both trials, treatment was an adjunct to lifestyle intervention (dietary counseling and at least 150 minutes per week of physical activity)

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