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The new WHO recommendations go well beyond those of its Essential Medicines List (EML) issued in September, which recommended the drugs only for diabetes

Importantly, this may not be absolute as growing evidence supports nuclei and/or celltype specific effects of GLP1 or GLP1 receptor agonists (with some action within the hypothalamus) to contribute to the regulation of glucose homeostasis (discussed further below)
Inositol-1, 4, 5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes

At the same time, new therapeutic approaches are emerging

doi: 10.3390/PHARMACEUTICS16101328
