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J Clin Endocrinol Metab (2020) 105(8):e2695709
[DOI] [PubMed] [Google Scholar] 232.Kandaswamy R, Sutherland DER
Although studies have found that metformin also affects 18 F-FDG accumulation in the colon, the mechanism is unclear ( 2.2 Increased GLP-1 secretion Metformin enhances the release of glucagon-like peptide-1 (GLP-1) from the intestines, potentially contributing to its ability to lower blood sugar levels ( The mechanism by which metformin increases GLP-1 secretion in the gastrointestinal tract is currently unclear
Neuroendocrinology of the pancreas: Role of brain-axis in pancreatic secretion
Beyond the effects validated in clinical trials, the GLP-1 and GIP/GLP-1 receptor agonists exhibit additional advantageous pleiotropic effects
Reduced appetite: Many people experience a decrease in hunger, which can contribute to weight loss
