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A., Winkley, K

10 or 15 mg once weekly) vs Reduce to tirzepatide 5 mg once weekly vs Placebo for 52 weeks (randomized 3:3:2 at week 60) Primary outcome: Percent change in bodyweight from baseline to week 112 Results: Primary outcome (percent change in bodyweight at week 112): Tirzepatide MTD -21.9%, Tirzepatide 5 mg -16.6%, Placebo -9.9% (estimated treatment difference vs placebo -12.0% for MTD and -6.6% for 5 mg

In contrast, human and pig islets express DPP4 almost exclusively in cells (130, 131)

doi:10.1172/JCI78371 Zheng Z, Zong Y, Ma Y, et al

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The advent of GLP-1RAs led to further discoveries that sustained GLP-1RAs exposure is associated with pro-survival cellular gene expression, purportedly mediated by cAMP responsive element binding (CREB) signalling that involves increased expression and/or activity of receptor tyrosine kinases PI3K/AKT, epidermal growth factor receptor (EGFR) and hypoxia-inducible factor 1-alpha (HIF-1) (Figure 1B) [1,4,7,26]