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Because GLP-1 receptor agonists are believed to be metabolized in various areas throughout the body and not specifically in the liver, 35 no significant variations were expected within any of the groups

Surgery is the last resort due to the risk for complications associated with these procedures

The SURPASS-CVOT trial, where dulaglutide at the dose of 1.5 mg/week or at the highest tolerated dose, is the comparator, has a distinctive design from the other trials: the primary endpoint is the time to the first manifestation of any major adverse CV event (MACE), defined as myocardial infarction, stroke or CV death

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As in the case of GLP-1RA, the significance of this finding which is reversible with discontinuation of therapy is unclear