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11 Importantly, structural modifications to GLP-1RAs can prolong their half-life to 5-7 days compared to the 1-5 minute long half-life of endogenous GLP-1

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doi: 10.3390/ijms25073812 [DOI] [PMC free article] [PubMed] [Google Scholar] 131.Rubin R

In some brain regions, GLP-1 receptor activation triggers both effects, but in others, like the hippocampus or the ventral tegmental area, food intake reduction occurs without nausea

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