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Someone with favorable GLP1 receptor variants may achieve their goal faster, while a patient with different genetic predispositions might benefit from combining semaglutide with oral options or adjusting the injection schedule

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Effect of Semaglutide on Coronary Atherosclerosis Progression in Patients with Type II Diabetes: Rationale and Design of the Semaglutide Treatment on Coronary Progression Trial
Neurology 87 (4), 419425

Room temperature exposure above 46F accelerates peptide breakdown and shortens shelf life significantly

For non-diabetic obesity, the cleanest comparison is between two separate trials: STEP 1 (semaglutide 2.4 mg, Wilding et al., NEJM 2021): 14.9% body weight loss at 68 weeks SURMOUNT-1 (tirzepatide 15 mg, Jastreboff et al., NEJM 2022): 20.9% body weight loss at 72 weeks A roughly 6 percentage point gap in average weight loss favors tirzepatide
