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Another translational gap arises from the limited generalizability of preclinical models [82]

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When you eat, GLP-1 signals your pancreas to release insulin, lowering blood sugar

In this setting, if gluconeogenic flux and/or glycogenolysis are also compromised as a result of inadequate substrates for gluconeogenesis (e.g., reduced AAs), subnormal glycogen storage (low caloric intake), or reduced counterregulatory hormones, hypoglycemia at late postprandial time points could ensue

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Additionally, the rise of e-prescriptions, telehealth integration, and subscription-based refill models have further supported the transition to digital pharmacy channels