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McEvoy RD, Antic NA, Heeley E, et al
GoF receptors are often characterised by a greater propensity for G protein versus -arrestin recruitment and signalling, slower rate of receptor internalisation and rapid recycling back to the plasma membrane, with these characteristics being independent of their surface expression levels (Liu et al., 2022)
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In T2DM patients, a single dose of tirzepatide delayed gastric emptying with a reduced effect over time
