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Description
Mounjaro (tirzepatide) : A newer medication that has shown promising results in glucose control and weight loss
Thus, GLP-1R G-protein-biased ligands may offer new and unappreciated advantages in the context of chronic treatment such as promoting adipocyte hyperplasia, restoring insulin responsiveness and long-term glycaemic control while preserving pancreatic -cell function by minimizing the insulin secretory burden

Realworld studies demonstrate high discontinuation rates of GLP1RAs by up to 75% within the first year of use, predominantly driven by side effects 20-22

Slowing your dose escalation, switching to a different GLP-1 formulation, or adjusting nutritional intake may resolve mood changes without discontinuing treatment
F., Mullenbach G

Given that obesity is a chronic and relapsing disease, it is important to understand the effectiveness of different strategies to maintain WL: TRIUMPH-6 (NCT06859268) will assess changes in bodyweight at 116 weeks in individuals with obesity who have completed 80 weeks of retatrutide, comparing continued treatment at high or low doses of retatrutide versus switching to placebo for the last 36 weeks