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Its premise is an upstream intervention targeting substantial weight reduction to improve key risk factors with the aim to avoid potential downstream complications from multiple co-morbidities, e.g., hypertension, dyslipidaemia, heart failure, kidney disease, NAFLD/NASH or diabetes

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Now the largest study of its kind suggests it and other medications like ithave a host of other potential health benefits beyond obesity, but could also bring increased risk of other conditions.