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Although long-term safety and efficacy require further evaluation, current evidence positions GLP-1 RAs as promising therapeutic agents in translational geroscience, with the potential to mitigate age-related physiological decline and promote a longer, healthier lifespan.
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Chronic cold stress in Glp1r-/-Gipr-/-, Glp1r-/-Glp2r-/-, and Glp2r-/- mice revealed distinct and overlapping roles for GLP-1R and GLP-2R in the expansion of the intestinal absorptive surface area expansion in response to chronic cold stress.