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How GLP-1 Medications Affect Fluid Needs GLP-1 medications such as Wegovy, Zepbound, Ozempic, and Mounjaro are highly effective, but they commonly cause gastrointestinal side effects including nausea, vomiting, diarrhea, and constipation

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Some people are unable to tolerate the drugs because of their side effects, particularly severe nausea and diarrheaa 2021 study showed 4.5 percent of people taking semaglutide discontinued the drug because of gastrointestinal issues

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Weight Loss One study found that after one year, participants with type 1 diabetes who took an SGLT-2 inhibitor had an average weight loss of 4.4 percent

First-time AOM semaglutide prescribing increased by over 50%, marking the largest quarter-over-quarter increase in first-time AOM semaglutide prescribing since mid-2024, likely driven by the approval of the oral formulation of Wegovy in December 2025