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Common AEs were nausea (23%), vomiting (6%), diarrhea (6%), constipation (10%), headache (6%), fatigue (8%), abdominal pain (2%), and abdominal bloating (2%)

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Compared with placebo (7.8%), relative muscle strength (strength normalized to body weight) was higher with exercise (0.4%), liraglutide (+1.0%), and the combined treatment (+3.3%) because of lower weight and preserved absolute strength

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Immune Impact: The study also showed that semaglutide helps "reset" the liver's immune environment, restoring healthy T cell and B cell populations that are usually depleted by high-fat diets

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