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Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) and dual agonist clinical guidance Herts and West Essex ICB

Two reviewers (KP and OR) independently extracted the data

One way this could be achieved would be if different hindbrain GLP-1-producing neurons have divergent projection targets and a different set of inputs

The gastrointestinal effects typically emerge during dose escalation and may diminish with continued use as physiologic adaptation occurs

2023 [cited 2025 Jan 24]

Wegovy is licensed in the UK in doses up to 2.4mg for weight loss and, on 14 September 2025, Novo Nordisk published results of a phase IIIb clinical trial (STEP UP, NCT05646706) of a 7.2mg dose of semaglutide for subcutaneous injection 1