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5 Safety, clinical tolerability, and periconception management strategies From the perspective of actionable clinical management, this section categorizes three core challenges associated with the use of GLP-1RAs in women of reproductive age with PCOS: (i) discontinuity in adherence driven by gastrointestinal adverse effects

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This review provides insights into the mechanisms by which GLP-1 and GIP modulate glucagon secretion and discusses findings on glucagon in the context of GLP-1 and GIP co-infusion studies as well as studies with novel unimolecular dual GIP/GLP-1 receptor agonists

Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone