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Description
While tirzepatide has demonstrated greater average weight loss in several studies, the best treatment option depends on the individual patient

With a half-life of approximately five days, drug levels decline to about 50% of peak by day five

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This is not true pharmacological tolerance in the classic sense, but rather the body finding a new equilibrium at the current level of receptor stimulation

It causes fragmented sleep, drops blood oxygen levels, increases cardiovascular risk, and destroys quality of life

In the SURMOUNT-5 head-to-head trial, tirzepatide achieved 20.2% average weight loss versus 13.7% for semaglutide over 72 weeks
