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Blautia, Coprococcus ), while these changes were absent with saxagliptin, consistent with its neutral effect on body weight ( Lachnospiraceae and partially reversed dysbiosis, while semaglutide uniquely increased Helicobacter , the only taxon negatively correlated with body weight ( Clostridium abundance and negatively correlated with renal injury markers, further supporting a microbiota-mediated mechanism ( Akkermansia ), further hinting at a positive remodeling of the gut ecosystem ( Interpretation of preclinical microbiome findings should consider the inherent limitations of rodent models

Interestingly, clinical trials reported to date on the effects of tirzepatide did include obese men and women, but results were not segregated by gender 47 , thus making it difficult to anticipate whether a sex dimorphism exist in GLP1/GIP responses

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