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That dual action already outperformed single-receptor drugs in clinical trials
But for people at risk of developing or relapsing into an eating disorder, such as anorexia or bulimia, these benefits can be triggering
80 demonstrated that this indole reduced LPS-induced inflammation and thus NLRP3 inflammasome formation in mouse adipose tissue by acting on the expression of inflammasome genes, including NLRP3, ASC, and thereby caspase-1 and IL-1
The other mouse study reported no difference in offspring weight at birth or maternal weight gain during pregnancy but did observe an increase in pre-weaning fetal growth after maternal exendin-4 (15)
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