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Abstract Heart failure (HF) remains one of the cardiovascular diseases (CVDs) associated with a high unmet medical need due to high morbidity and mortality rates and lack of efficacious interventions

received honoraria for speaking at meetings from Novartis, Sanofi, Lilly, Astrazeneca, and NovoNordisk

DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy

[DOI] [PubMed] [Google Scholar] 22.Deacon C.F., Johnsen A.H., Holst J.J
A summary of FDA-approved GLP-1RAs is depicted in Table 1
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In healthy and diabetic subjects, the co-agonist displayed to improve glucose tolerance and insulin secretion, although no data regarding bodyweight, lipid metabolism, or liver function were reported ( This approach with dual agonists has been followed by the development of monomeric triagonists, incorporating residues from GLP-1, glucagon and GIP
