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Thyroid Function Monitoring For patients established on levothyroxine, thyroid function tests (TSH and free T4) should be monitored according to standard protocols: Every 612 months once stable on an established dose 68 weeks after any dose adjustment 68 weeks after starting or changing the dose of Saxenda After significant weight loss or gain More frequently if symptoms of hypo- or hyperthyroidism develop Patients should report symptoms suggesting inadequate thyroid replacement (fatigue, cold intolerance, weight gain, constipation) or excessive replacement (palpitations, tremor, anxiety, heat intolerance, unintentional weight loss)

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It mimics one gut hormone, glucagon-like peptide-1, which reduces appetite, slows gastric emptying, and improves insulin sensitivity

Gastrointestinal side effects: GLP-1-based agents, including retatrutide, commonly cause nausea, vomiting, diarrhoea, and reduced appetite, partly through slowing of gastric emptying

[51] found that linagliptin decreases aortic pulse wave velocity (PWV), a surrogate marker for arterial stiffness and early atherosclerosis, by an average of 0.91 m/s