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Similarly, sleeping metabolic rate (defined as 3-h EE during the period with lowest spontaneous physical activity (a surrogate marker of REE)) was lower for liraglutide 1.8 and 3.0 mg versus placebo (3%, P =0.04 and P =0.05, respectively)

Clinical research hints at a nuanced picture: interestingly, one trial with a GLP-1 analog (ROSE-010) noted that low doses actually accelerated colonic transit at 48 hours, possibly helping constipation, while higher doses mainly delayed stomach empty

Additionally, subtherapeutic dosing from degraded medication may result in inadequate glycemic control for patients with type 2 diabetes

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