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High costs, variable insurance coverage, and the risks associated with non-approved compounded products can limit safe access

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally developed to manage type 2 diabetes mellitus

Ecnoglutide's approximately 2% AE discontinuation rate and CT-388's 5.9% rate despite 22.5% weight loss suggest that biased agonism may meaningfully improve the tolerability-efficacy equation

Incretin agonist clinical trials most frequently reveal nausea as an adverse effect

The 10mg/ml concentration hits the sweet spot for most users

Safety issues have also been raised on a possible association between incretin-based drugs and pancreatitis or pancreatic cancer based on animal studies and data on patients (62)