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The GLP-1 receptor is expressed on the surface of cells across many different tissues, including the pancreas, intestines, liver, central and autonomic nervous systems, immune system, heart, and muscle

By suppressing gluconeogenesis in the liver, metformin lowers fasting blood glucose levels without causing hypoglycaemia

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299 Mechanisms of harm appear likely varied and could include changes to the food matrix

Theres still a bit of uncertainty around how GLP-1 medications affect the gut microbiome
