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This connection between the gut & pancreatic islets may be responsible for ~50% of postprandial insulin release (Perley & Kipnis, J Clin Invest 46:1954-1962

In the short term, these outcomes appear similar to those achieved through bariatric/metabolic surgical procedures

Comparison between physiologic and erythromycin-induced interdigestive motility

Tirzepatide may be the better choice if: You need to lose 15% or more of your body weight

This degradation is catalyzed by the ubiquitous serum enzyme dipeptidyl peptidase 4 (DPP-4), which is produced both locally in the intestine and by circulating white blood cells

doi: 10.1111/bcp.15816 [DOI] [PubMed] [Google Scholar] 186.Petri KCC, Ingwersen SH, Flint A, Zacho J, Overgaard RV