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We delineate how systemic metabolic dysfunction, often associated with obesity, synergizes with local inflammation to alter the balance between MMPs and their tissue inhibitors TIMPs, thus contributing to a perpetuating circle of inflammation and fibrosis

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With GLP-1 adoption accelerating, size is changing, but so is identity

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Methods We performed a retrospective cohort study using TriNetX database to evaluate adult patients who carried the diagnosis of RA from January 1, 2006 to December 1, 2024 with co-existing T2DM and who initiated GLP-1 analogs or DPP4i after diagnosis of RA and T2DM