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MTBE was added to reaction mixture and stirred for 15 min at same temperature

Small amounts add up

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FDA Announcement on Carvykti Oncology Nursing Society: ONC Voice: FDA Approves Boxed Warning Kineret (Anakinra) and Injection Site Reactions Rheumatoid arthritis (RA) drug Kineret (Anakinra) had a label update to warn that cases of injection site amyloid deposits (build-up of abnormal proteins) have been reported in patients after receiving high doses of Kineret injected subcutaneously into the same area of skin over long periods of time