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The growing prevalence of metabolic disease, CKD, and ASCVD have prompted investigation into the role of GLP-1R agonists in mitigating cardiovascular and metabolic risks, particularly within the framework of Cardiovascular-Kidney-Metabolic (CKM) Syndrome, irrespective of diabetic status

Diabetes 60(12):31033109 Yanagimachi T, Fujita Y, Takeda Y et al (2016) Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (130) expression is upregulated in diabetes and PEGylated GIP(130) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice

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Other warnings include pancreatitis, gallbladder issues, vision changes (especially diabetic retinopathy), and risk of low blood sugar when used with other diabetes medications