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[13] Fasting levels of insulin-like growth factor (IGF) binding proteins such as IGFBP1 and IGFBP2 increased after tirzepatide treatment, increasing insulin sensitivity
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Tirzepatides dual mechanism addresses this cycle at two points simultaneously: GLP-1 agonism improves insulin secretion and sensitivity at the pancreatic level, while GIP agonism appears to modulate lipid handling in adipocytes
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Lancet Diabetes Endocrinol 5(5):341354
