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Importantly, it does not typically drive insulin release under low-glucose conditions, reducing hypoglycemia risk in research settings

Diabetes Care 34(Supplement_2):S279-84 [DOI] [PMC free article] [PubMed] [Google Scholar] Gerstein HC, Colhoun HM, Dagenais GR, Diaz R, Lakshmanan M, Pais P et al (2019) Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

How GLP-1s cause weight loss may further complicate whether they can be considered performance-enhancing

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Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the surmount-4 randomized clinical trial