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Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]

Tirzepatide 15 mg was also associated with higher incidence of vomiting (OR 5.50 [95% CI 2.40, 12.59], I 2 0%) and diarrhoea (OR 3.31 [95% CI 1.40, 7.85], I 2 52%), while more participants receiving tirzepatide 10 mg experienced vomiting (OR 2.98 [95% CI 1.13, 7.80], I 2 0%) (Table 2)

The United States National Health and Nutrition Examination Survey 20112020

These mechanisms are specified below

Bosch-Traberg, M

Diabetes Obes Metab (2016) 18(1):7281