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Predefined sensitivity analyses to determine potential confounding influence were conducted with the same statistical analysis set-up removing (1) patients with IIH without papilledema (IIH-WOP), and (2) patients with pre-existing migraine

Bhatti JA, Nathens AB, Thiruchelvam D, Grantcharov T, Goldstein BI, Redelmeier DA

Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism

But then I have to go from biology to chronic relapsing disease

But it was reported in studies of metformin (an active ingredient in these drugs)