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Description
Consider this scenario: a 38-year-old man presents with fatigue, reduced libido, difficulty concentrating, and a BMI of 36
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The accumulation of fibrillar collagensparticularly collagen type VI alpha 3 chain (COL6A3) and collagen Iis a hallmark of metabolically impaired adipose depots, and their crosslinking by lysyl oxidase (LOX) further increases ECM rigidity and mechanical stress on adipocytes [53]
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