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While the foundations of a healthy lifestyle will always begin with diet and exercise, and bariatric procedures can be the right choice for patients with the chronic health issues associated with severe obesity, GLP-1 receptor agonists provide another safe, effective, and measured approach

Common Gastrointestinal Concerns Both dual and triple agonists share a class-wide side effect profile dominated by gastrointestinal issues, primarily: Nausea Diarrhea or Constipation Vomiting These effects are dose-related and typically peak during the dose-escalation phase

Weakly informative priors were used

Purpose ELIXA was conducted to assess the cardiovascular safety of once-daily subcutaneously injected lixisenatide 20 mcg (Adlyxin) by documenting non-inferiority, as well as superiority, for the primary composite outcome of non-fatal myocardial infarction, non-fatal stroke, CV death, or hospitalization for unstable angina (4-point MACE) in an adult population with T2DM and extremely high CV risk