glp-1 ncbi Emerging Frontiers in Therapeutics: A Comprehensive Evidence Base (2025) GLP-1 actions and target organs.

Background Despite the effectiveness of glucagon-like peptide-1 agonist (GLP-1A) in the treatment of diabetes, its large molecular weight and high hydrophilicity result in poor cellular permeability, thus limiting its oral bioavailability

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Here, the authors show that remote ischaemic preconditioning releases the gut hormone GLP-1, which relaxes cardiac pericytes via KATP channels to reduce capillary constriction and no-reflow.

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