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In humans, case reports and small-scale studies have observed that weight loss in obese patients treated with GLP-1RAs coincides with amelioration of anxiety symptoms

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Studies in animals have found that GLP-1 mediates 5 adenosine monophosphate-activated protein kinase (AMPK) phosphorylation by activating GLP-1R signaling, thereby regulating skeletal muscle remodeling and enhancing exercise tolerance, while glycogen synthesis, glucose uptake, type I muscle fiber proportion, and mitochondrial biosynthesis are enhanced in the skeletal muscles of GLP-1-AAV treated mice [19]

Given that the skin on the hands is thin, the decline in collagen levels becomes more noticeable, leading to wrinkles