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Acknowledgements We, and Eli Lilly and Company, thank the clinical trial participants and their caregivers, as well as the clinical trial investigators (listed in Supplementary Information), without whom this work would not have been possible

Patients taking SGLT2 inhibitors (such as empagliflozin) or GLP-1 agonists should speak with their doctor about continuing these alongside tirzepatide, as this combination requires specialized oversight

Hormonal Changes: The Hidden Variable GLP-1s also influence hormonal balance , which plays a key role in libido for both men and women

Tirzepatide might indirectly increase the risk of TMJD if it causes muscle tension, sleep disturbances, or nausea that leads to clenching the jaw

According to a 2022 study published in The Lancet , patients on tirzepatide experienced an average weight loss of up to 22.5% of their initial body weight over a 72-week period