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Does Incretin Agonism Have Sustainable Efficacy

Semaglutide has a seven-day half-life, which means it takes approximately four to five weeks to reach steady state at any given dose

Patients taking GLP-1 medications should consult their healthcare provider before initiating magnesium supplementation, particularly if they have underlying medical conditions or are taking other medications

PLoS ONE, 7, e45167

Treatment duration varies by patient

As a specific example: do these multi-agonists act simultaneously at multiple receptors residing at a single tissue or even a single cell
