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These experiments support the notion that MK-801 does not enhance the pharmacokinetics of gut peptides and that the additional metabolic benefits and synergistic weight loss effects brought about by MK-801 are dependent on NMDA receptor antagonism in GLP-1-receptor-positive neurons

A study using dual-energy X-ray absorptiometry (DEXA) scanning to determine if there was a difference in adipose distribution among patients with IIH and obesity and those without IIH and obesity showed a correlation between increased truncal adiposity and increased CSF pressure [3]

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The effects of ER once-weekly have been compared to exenatide twice-daily and overall ER was more effective at improving glycemic control and caused less gastrointestinal side-effects although both compounds caused a similar degree of weight loss (Drucker et al., 2008

SGLT2i blocks glucose reabsorption in the proximal tubules of the kidney and increases glucosuria, as well as blocking sodium resorption and leading to sodium excretion in the urine [1]