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Persistence beyond the initial adjustment period warrants clinical review for dose modification or supportive treatment

Here's a quick summary: Appetite reduction often begins within 12 weeks

"Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes." J Clin Endocrinol Metab

Yeah, but you're 80 years old

Notably, history of cardiovascular disease was present in 86.9% of participants from SURPASS-4, whereas the prevalence of such conditions in the other trials was 5.418.3% (Supplementary Table 3)

Only people who have been carefully titrated up over many months under medical supervision should be anywhere near this level