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A growing body of evidence shows associations of genetic variants of TPH1/2, SERT, and 5-HTRs with metabolic diseases such as obesity, T2D, and MAFLD [186192]

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In the new substudy, once weekly semaglutide (1 mg) was shown to reduce the risk of time to first composite HF event (new onset or worsening HF leading to unscheduled hospital admission or urgent visit, with initiation of or intensified diuretic/vasoactive therapy) or cardiovascular death and HF events and cardiovascular death alone
