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Tirzepatide adds the GIP component

These medications mimic the action of the glucagon-like peptide-1 hormone, stimulating insulin release, inhibiting glucagon secretion, and delaying gastric emptying, said Jeffrey Joseph, MD, an oculofacial plastic surgeon in private practice in Newport Beach, California

Semaglutide is the active ingredient in weight loss drugs like Novo Nordisk's Ozempic and Wegovy, which have been hailed as "miracle drugs" for not only treating obesity but also treating weight-related ailments like diabetes and high blood pressure

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For some, these side effects may prevent them from increasing the dosage, which is necessary for optimal weight loss