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8 In addition to the anti-diabetic effects, weight loss has also been observed in patients receiving SGLT-2i monotherapy

While that is less than the more than 20% seen with some injectable options, Egan said the results are still meaningful

By reversibly binding glucokinase (GK), GCKR modulates GKs localization and enzymatic activity, serving as both a metabolic sensor and a safeguard against excessive glucose flux ( Genetic variants in GCKR have garnered attention due to their associations with diverse metabolic traits, including elevated fasting triglycerides, altered insulin sensitivity, and increased risk of MASLD (119121)

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