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Rapid loss raises gallstone risk, increases muscle loss, and may cause nutrient deficiencies

Drop 100-plus pounds and sagging skin is likely

Nuffer W, Guesnier A, Trujillo JM
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A 16% weight loss for a 220-pound person is about 35 pounds

Patients experiencing new or worsening vasomotor symptoms should undergo appropriate clinical evaluation to identify the underlying cause and rule out other contributing factors that may require specific management
