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You are asking your body to make something that partially burns fat versus giving it a compound that was engineered specifically to burn fat at record levels
(2.2, 2.3) Dosage: 300 mg nirmatrelvir (two 150 mg tablets) with 100 mg ritonavir (one 100 mg tablet), with all 3 tablets taken together twice daily for 5 days

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[DOI] [PubMed] [Google Scholar] 219.Bode BW, Testa MA, Magwire M, et al
