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Physicians also screen for exclusion criteria including pregnancy plans, certain gastrointestinal conditions, and drug interactions that could affect safety or efficacy

[33, 34, 35, 36] Mechanism: Typically pre-renal, occurring in the setting of volume depletion from GI losses (nausea, vomiting, diarrhea, reduced oral intake) More frequently seen at higher, obesity-level doses Although generally reno-protective long term, post-marketing data describe acute rises in creatinine following days to weeks of significant GI symptoms Risk factors: Underlying chronic kidney disease Concomitant use of ACE inhibitors, ARBs, diuretics, or SGLT2 inhibitors ED Management: IV fluids Hold GLP-1 and contributing medications Usually reversible with supportive care Future Directions GLP-1 receptor agonists are rapidly evolving beyond their original indications in diabetes and obesity

Most importantly, alongside medication, healthy lifestyle habits and informed dietary choices play a key role in supporting long-term metabolic health

Unlike pure dietary measures, weight loss may be sustained for up to a period of 3 years in the presence of GLP-1 agonist therapy [67, 68]

Self-pay patients can access Wegovy at reduced prices of $199 to $249 per month through the manufacturers self-pay savings program

This article examines the potential anti-inflammatory mechanisms of GLP-1 medications, compares available agents, and discusses what patients should consider when speaking with their GP about these treatments